The Effect of Tortuosity on Permeability of Porous Scaffold.

In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone. In this study, a porous scaffold was developed according to the morphological indices of cancellous bone (porosity, specific surface area, thickness, and tortuosity). The computational fluid dynamics method analyzes the fluid flow through the scaffold. The permeability values of natural cancellous bone and three types of scaffolds (cubic, octahedron pillar, and Schoen's gyroid) were compared. The results showed that the permeability of the Negative Schwarz Primitive (NSP) scaffold model was similar to that of natural cancellous bone, which was in the range of 2.0 × 10-11 m2 to 4.0 × 10-10 m2. In addition, it was observed that the tortuosity parameter significantly affected the scaffold's permeability and shear stress values. The tortuosity value of the NSP scaffold was in the range of 1.5-2.8. Therefore, tortuosity can be manipulated by changing the curvature of the surface scaffold radius to obtain a superior bone tissue engineering construction supporting cell migration and tissue regeneration. This parameter should be considered when making new scaffolds, such as our NSP. Such efforts will produce a scaffold architecturally and functionally close to the natural cancellous bone, as demonstrated in this study.

Characteristics of a PVDF-Tin Dioxide Membrane Assisted by Electric Field Treatment.

Polymeric membranes have good properties for filtering water. In this paper, a membrane made from polyvinylidene fluoride (PVDF) polymer with 15 wt%, 17.5 wt%, and 20 wt% polymer content, with the addition of 1 wt% of tin dioxide with electric field treatment, is presented. The electric field used was DC 15,000 V. The membrane was tested to determine its characteristics and properties. The physical properties were examined with a scanning electron microscope, and the mechanical properties of the membrane were tested by tensile testing. The maximum tensile stress was obtained at 0.746 MPa, and the minimum tensile stress was obtained at 0.487 MPa. Microscopic examination of the membrane's surface identified the shape, the structure of the fibers formed, and the amount of agglomeration. The flow rate, membrane flux, and normalized water permeability (NWP) were tested, using the water treatment performance test to measure the membrane's filtering ability.